Surface modification of chrysotile asbestos with organic reagents:with organic reagents: a preliminary in vitro toxicological study

CIM Bulletin, Vol. 84, No. 945, 1991

Fathi Habashi, Farouk T. Awadalla, Department of Mining and Metallurgy, Universite Laval, Quebec, and Michel Page, Department of Biochemistry, Faculty of Medicine, Universite Laval, Quebec

Chrysotile asbestos can be dyed with certain dyestuffs to form stable coloured products whose hemolytic and cytotoxicity are greatly reduced. Examples of these dyes are Thiazol Yellow G (a monazo dye) and Trypan Blue (a diazo dye). Other dyestuffs, for example, basic dyes with triphenylmethane structure, Brilliant Yellow (a diazo dye), and Methylene Blue (a thiazine dye) colour asbestos but do not reduce its toxicity. Similarly alizarin, 8-hydroxyquinoline, and representative members of the phthalein group Bromocresol Purple and Phenolphthalein.
Keywords: Chrysotile asbestos, Dyestuffs, Cytotoxicity, Hemolysis.